Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?

Grgurević, Lovorka; Novak, Ruđer; Jambrošić, Lucija; Močibob, Marko; Jaganjac, Morana; Halasz, Mirna; Salai, Grgur; Hrkač, Stela; Milošević, Milan; Vlahović, Tomislav; Romić, Jeronim; Matičić, Dražen; Vidović, Dinko (2024) Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?. Bioengineering, 11 (11). ISSN 2306-5354

PDF - Published Version - article Available under License Creative Commons Attribution. Download (2MB)

Abstract

Introduction: Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation. Materials and methods: We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12). Results: We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3–74, immunoglobulin lambda variable 2–18, low-density lipoprotein receptor-related protein 4, zinc-alpha-2-glycoprotein, and serum amyloid A-1 protein; and we found one downregulated protein: cystatin-C. The metabolomic study found differences in alanine, aspartate and glutamate metabolism pathways between two groups. Conclusions: The combined results of proteomic and metabolomic analyses suggest that the dysregulation of lipid metabolism may contribute to non-union formation.

Item Type:	Article
Uncontrolled Keywords:	bone healing; bone fracture; non-union; proteomics; metabolomics
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Depositing User:	Ivana Vuglec
Date Deposited:	10 Dec 2025 13:09
URI:	http://fulir.irb.hr/id/eprint/10134
DOI:	10.3390/bioengineering11111135

Actions (login required)

View Item