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Recent Achievements in Simulated Moving Bed (SMB) Technology. Part I.

Šunjić, Vitomir; Franić, Dean; Kontrec, Darko; Roje, Marin (2010) Recent Achievements in Simulated Moving Bed (SMB) Technology. Part I.. Kemija u industriji, 59 (6). pp. 283-294. ISSN 0022-9830

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Abstract

Simulated moving bed (SMB) technology is over half a century known in continuous chromatographic separation of binary mixtures. Invented and developed in the petrochemical and sugar industries, it was recognized by organic chemists in the pharmaceutical industry as a powerful tool in separation of racemic mixtures. Over the years, it was developed into a standard laboratory, then pilot-plant and finally large-scale method for production of chiral compounds in the optically pure form. Final products of this technology are enantiopure drugs, other biologically active compounds and their intermediates. In Part I of this review, the basic principles and selected examples of recent SMB technology applications are presented.

Item Type: Article
Uncontrolled Keywords: simulated moving bed; continuous chromatography; triangle theory; enantioseparation
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Kiralni organski materijali – sintetska, strukturna i funkcionalna istraživanja[71214] Vladimir Vinković098-0982904-2910MZOS
Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost[15212] Zdenko Hameršak098-0982933-2908MZOS
Depositing User: Marin Roje
Date Deposited: 11 Dec 2013 09:26
Last Modified: 26 Feb 2014 11:05
URI: http://fulir.irb.hr/id/eprint/1005

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