Plant-Mediated Synthesis of Magnetite Nanoparticles with Matricaria chamomilla Aqueous Extract

Paut, Andrea; Guć, Lucija; Vrankić, Martina; Crnčević, Doris; Šenjug, Pavla; Pajić, Damir; Odžak, Renata; Šprung, Matilda; Nakić, Kristian; Marciuš, Marijan; Prkić, Ante; Mitar, Ivana (2024) Plant-Mediated Synthesis of Magnetite Nanoparticles with Matricaria chamomilla Aqueous Extract. Nanomaterials, 14 (8). ISSN 2079-4991

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Abstract

Magnetite nanoparticles (NPs) possess properties that make them suitable for a wide range of applications. In recent years, interest in the synthesis of magnetite NPs and their surface functionalization has increased significantly, especially regarding their application in biomedicine such as for controlled and targeted drug delivery. There are several conventional methods for preparing magnetite NPs, all of which mostly utilize Fe(iii) and Fe(ii) salt precursors. In this study, we present a microwave hydrothermal synthesis for the precipitation of magnetite NPs at temperatures of 200 °C for 20 min and 260 °C for 5 min, with only iron(iii) as a precursor utilizing chamomile flower extract as a stabilizing, capping, and reducing agent. Products were characterized using FTIR, PXRD, SEM, and magnetometry. Our analysis revealed significant differences in the properties of magnetite NPs prepared with this approach, and the conventional two-precursor hydrothermal microwave method (sample MagH). FTIR and PXRD analyses confirmed coated magnetite particles. The temperature and magnetic-field dependence of magnetization indicate their superparamagnetic behavior. Importantly, the results of our study show the noticeable cytotoxicity of coated magnetite NPs—toxic to carcinoma cells but harmless to healthy cells—further emphasizing the potential of these NPs for biomedical applications.

Item Type:	Article
Uncontrolled Keywords:	green synthesis; magnetite; Matricaria chamomilla aqueous extract; biocompatibility; plant magnetic nanoparticle biogenesis
Subjects:	NATURAL SCIENCES > Physics NATURAL SCIENCES > Chemistry
Divisions:	Division of Materials Chemistry Division of Materials Physics
Projects:	Project title Project leader Project code Project type Razvoj novih membrana za ionsko-selektivne elektrode s dodatkom nanočestica metala i metalnih oksida-NANOISEM Perica Bošković; Ivana Mitar; Ante Prkić UIP-2017-05-6282 HRZZ Evolucija složenih magnetskih i polarnih uređenja iz jednostavnih 2D podstruktura u slojevitim hibridnim organsko-anorganskim halogenometalatima (HOI2DEM) Damir Pajić IP-2022-10-6321 HRZZ Centar za Napredna Istraživanja Kompleksnih Sustava-CeNIKS Mihael Srđan Grbić; Emil Tafra KK.01.1.1.02.0013 EK Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri-QuantiXLie Hrvoje Buljan; Pavle Pandžić; Vit Tuček; Tomislav Marketin KK.01.1.1.01.0004 EK
Depositing User:	Ivana Vuglec
Date Deposited:	17 Oct 2025 12:03
URI:	http://fulir.irb.hr/id/eprint/10025
DOI:	10.3390/nano14080729

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