Anaphase B: Long-standing models meet new concepts

Vukušić, Kruno; Tolić, Iva Marija (2021) Anaphase B: Long-standing models meet new concepts. Seminars in Cell & Developmental Biology, 117 . pp. 127-139. ISSN 1084-9521

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Sažetak

Mitotic cell divisions ensure stable transmission of genetic information from a mother to daughter cells in a series of generations. To ensure this crucial task is accomplished, the cell forms a bipolar structure called the mitotic spindle that divides sister chromatids to the opposite sides of the dividing mother cell. After successful establishment of stable attachments of microtubules to chromosomes and inspection of connections between them, at the heart of mitosis, the cell starts the process of segregation. This spectacular moment in the life of a cell is termed anaphase, and it involves two distinct processes: depolymerization of microtubules bound to chromosomes, which is also known as anaphase A, and elongation of the spindle or anaphase B. Both processes ensure physical separation of disjointed sister chromatids. In this chapter, we review the mechanisms of anaphase B spindle elongation primarily in mammalian systems, combining different pioneering ideas and concepts with more recent findings that shed new light on the force generation and regulation of biochemical modules operating during spindle elongation. Finally, we present a comprehensive model of spindle elongation that includes structural, biophysical, and molecular aspects of anaphase B.

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Ključne riječi:

Anaphase B Spindle elongation Motor proteins Microtubule sliding Chromosome segregation Microtubule pushing Microtubule pulling

Područja:

PRIRODNE ZNANOSTI > Fizika > Biofizika i medicinska fizika
PRIRODNE ZNANOSTI > Biologija > Biokemija i molekularna biologija

Zavodi:

Zavod za molekularnu biologiju

Projekti:

Naziv projekta	Voditelj projekta	Šifra projekta	Vrsta projekta
Molecular origins of aneuploidies in healthy and diseased human tissues	Tolić, Iva Marija; Pavin, Nenad	855158	EK
Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena	Tolić, Iva	PZS-2019-02-7653	HRZZ
Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini	Tolić, Iva Marija	KK.01.1.1.04.0057	EK
Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri	Buljan, Hrvoje; Pandžić, Pavle	KK.01.1.1.01.0004	EK
A new class of microtubules in the spindle exerting forces on kinetochores	Tolić, Iva Marija	647077	EK