Shichkin, Valentin P.; Felli, Maria Pia; Screpanti, Isabella; Antica, Mariastefania (2022) Editorial: Thymus function and aging: A focus on thymic epithelial cells. Frontiers in Immunology, 13 . ISSN 1664-3224
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Abstract
The thymus is an unique organ in its ability to support the maturation of phenotypically and functionally distinct T cell sublineages and innate immune cells, which carry out multiple tasks to keep the organism healthy. Entering the thymus, lymphocyte precursors interact with the thymic stromal compartment mainly built of different thymic epithelial cells (TECs) and other non-lymphoid cells comprising the thymic microenvironment for T cell development (1). From the enormous variety of produced T lymphocytes, only a minor part can survive a rigorous checkpoint control and selection during this crosstalk (2). However, some physiological factors, including aging, stress, and pregnancy, as well as medical procedures such as thymectomy and chemo/radiotherapy, can harm the thymus function, which is associated with the decline of immune function and the risk of tumors and infectious and autoimmune diseases.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | thymus regeneration and development; thymic stem cells; thymic epithelial cells; T cell development; thymus regeneration | ||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Immunology |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Kristina Ciglar | ||||||||
| Date Deposited: | 14 Jul 2026 13:40 | ||||||||
| URI: | https://fulir.irb.hr:/id/eprint/12065 | ||||||||
| DOI: | 10.3389/fimmu.2022.1003490 |
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