Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach

Zahirović, Adnan; Osmanković, Irnesa; Osmanović, Amar; Višnjevac, Aleksandar; Magoda, Amina; Hadžalić, Selma; Kahrović, Emira (2023) Interaction of Copper(II) Complexes of Bidentate Benzaldehyde Nicotinic Acid Hydrazones with BSA: Spectrofluorimetric and Molecular Docking Approach. Acta Chimica Slovenica, 70 (1). pp. 74-85. ISSN 1318-0207

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Abstract

Two copper(II) complexes of 4-chloro- and 4- dimethylaminobenzaldehyde nicotinic acid hydrazones were prepared and characterized by elemental analysis, mass spectrometry, infrared and electron spectroscopy and conductometry. These rare examples of bis(hydrazonato)copper(II) complexes are neutral complex species with copper(II) center coordinated with two monoanionic bidentate O, N-donor hydrazone ligands coordinated in enol-imine form. The interaction of hy-drazone ligands and corresponding copper(II) complexes with CT DNA and BSA was investigated. Copper(II) complex-es are slightly effective in binding the DNA than pristine hydrazones. The results indicate groove binding or moderate intercalation which are not significantly affected by the nature of substituent at hydrazone ligands. On contrary, affinities of two copper(II) complexes toward BSA significantly differs and depends on the nature of the substituent, however in absence of thermodynamic data difference in nature of binding forces cannot be excluded. The complex bearing elec-tron-withdrawing 4-chloro substituent has larger affinity toward BSA compared to 4- dimethyamino analogue. These findings were theoretically supported by molecular docking study.

Item Type:	Article
Uncontrolled Keywords:	Copper; nicotinic acid; hydrazone; bidentate; CT DNA; BSA
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Chemistry
Divisions:	Division of Physical Chemistry
Depositing User:	Kristina Ciglar
Date Deposited:	28 Apr 2026 14:05
URI:	https://fulir.irb.hr:/id/eprint/11815
DOI:	10.17344/acsi.2022.7826

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