Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function

Sikirić, Predrag; Gojković, Slaven; Krezić, Ivan; Smoday, Ivan Maria; Kalogjera, Luka; Žižek, Helena; Oroz, Katarina; Vraneš, Hrvoje; Vuković, Vlasta; Labidi, May; Štrbe, Sanja; Baketić Orešković, Lidija; Sever, Marko; Tepeš, Marijan; Knežević, Mario; Barišić, Ivan; Blagaić, Vladimir; Vlainić, Josipa; Dobrić, Ivan; Starešinić, Mario; Škrtić, Anita; Jurjević, Ivana; Boban Blagaić, Alenka; Seiwerth, Sven (2023) Stable Gastric Pentadecapeptide BPC 157 May Recover Brain–Gut Axis and Gut–Brain Axis Function. Pharmaceuticals, 16 (5). ISSN 1424-8247

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Official URL: https://www.mdpi.com/1424-8247/16/5/676

Abstract

Conceptually, a wide beneficial effect, both peripherally and centrally, might have been essential for the harmony of brain-gut and gut-brain axes' function. Seen from the original viewpoint of the gut peptides' significance and brain relation, the favorable stable gastric pentadecapeptide BPC 157 evidence in the brain-gut and gut-brain axes' function might have been presented as a particular interconnected network. These were the behavioral findings (interaction with main systems, anxiolytic, anticonvulsive, antidepressant effect, counteracted catalepsy, and positive and negative schizophrenia symptoms models). Muscle healing and function recovery appeared as the therapeutic effects of BPC 157 on the various muscle disabilities of a multitude of causes, both peripheral and central. Heart failure was counteracted (including arrhythmias and thrombosis), and smooth muscle function recovered. These existed as a multimodal muscle axis impact on muscle function and healing as a function of the brain-gut axis and gut-brain axis as whole. Finally, encephalopathies, acting simultaneously in both the periphery and central nervous system, BPC 157 counteracted stomach and liver lesions and various encephalopathies in NSAIDs and insulin rats. BPC 157 therapy by rapidly activated collateral pathways counteracted the vascular and multiorgan failure concomitant to major vessel occlusion and, similar to noxious procedures, reversed initiated multicausal noxious circuit of the occlusion/occlusion-like syndrome. Severe intracranial (superior sagittal sinus) hypertension, portal and caval hypertensions, and aortal hypotension were attenuated/eliminated. Counteracted were the severe lesions in the brain, lungs, liver, kidney, and gastrointestinal tract. In particular, progressing thrombosis, both peripherally and centrally, and heart arrhythmias and infarction that would consistently occur were fully counteracted and/or almost annihilated. To conclude, we suggest further BPC 157 therapy applications.

Item Type:

Article

Uncontrolled Keywords:

gastric pentadecapeptide BPC 157; brain–gut axis; gut–brain axis; occlusion syndrome; occlusion-like syndrome; heart failure; encephalopathy; muscle

Subjects:

BIOMEDICINE AND HEALTHCARE
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences

Divisions:

Division of Molecular Medicine

Projects: