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Supramolecular intermediates in thermo-mechanochemical direct amidations

Stolar, Tomislav; Alić Stolar, Jasna; Talajić, Gregor; Cindro, Nikola; Rubčić, Mirta; Molčanov, Krešimir; Užarević, Krunoslav; Hernández, José G. (2023) Supramolecular intermediates in thermo-mechanochemical direct amidations. Chemical Communications, 59 (90). pp. 13490-13493. ISSN 1359-7345

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We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Detailed analysis of the reactions by ex situ and in situ monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.

Item Type: Article
Uncontrolled Keywords: mechanochemistry; moclobemide; intermediates; pharmaceutical;
Subjects: NATURAL SCIENCES > Chemistry > Organic Chemistry
NATURAL SCIENCES > Chemistry > Applied Chemistry
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEMKrunoslav UžarevićIP-2020-02-4702HRZZ
In situ monitoring of mechanochemical cocrystal formation by synchrotron XRDTomislav StolarI-20220019 ECInternal DESY
Depositing User: Krunoslav Užarević
Date Deposited: 21 Feb 2024 09:36
DOI: 10.1039/D3CC04448C

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