Multiresidue analysis, bioaccumulation potential and occurrence of pharmaceuticals in freshwater fish

Ivanković Koprivić, Klaudija (2026) Multiresidue analysis, bioaccumulation potential and occurrence of pharmaceuticals in freshwater fish. Doctoral thesis, Institut Ruđer Bošković.

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Abstract

When released into the environment, pharmaceuticals (PhACs), a broad and varied class of physiologically active compounds, can become a serious environmental hazard. The ability of PhACs to accumulate in aquatic species is the main predictor of the severity of their adverse impacts. One of the key prerequisites for a reliable ecotoxicological risk assessment of environmental contamination with PhACs is the development of analytical methods for the simultaneous determination of PhAC mixtures in biota. In this thesis, novel multiresidue analytical methods for the trace determination of 44 selected PhACs and their metabolites in river water and fish tissue were developed. The kinetics of accumulation and elimination, metabolic transformations, and bioaccumulation potential of 20 selected PhACs were investigated by applying these methods in model experiments with the cyprinid organism Danio rerio. The final stage of this research was a field study, which aimed to quantify the impact of pharmaceuticals on the Sava River's wild fish population in the wider area of the city of Zagreb.

Item Type:	Thesis (Doctoral thesis)
Uncontrolled Keywords:	bioaccumulation; ecotoxicological risk assessment; metabolism; multiresidue analysis; pharmaceutically active compounds; pharmacokinetics; the Sava River
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Analytic Chemistry NATURAL SCIENCES > Interdisciplinary Natural Sciences > Environmental Science
Divisions:	Division for Marine and Enviromental Research
Projects:	Project title Project leader Project code Project type Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija-PHARMA-RISK Senka Terzić IP-2019-04-9519 HRZZ Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija - DOK Senka Terzić DOK-2020-01-9250 HRZZ
Depositing User:	Klaudija Ivanković Koprivić
Date Deposited:	18 Sep 2026 07:23
URI:	https://fulir.irb.hr:/id/eprint/12138

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