Ternary Coordination Compounds of Copper(II) with Glycine and 2,2'-bipyridine: Synthesis, Structural Characterization, Magnetic and Biological Properties

Vušak, Darko; Mišković Špoljarić, Katarina; Jurec, Jurica; Žilić, Dijana; Prugovečki, Biserka (2023) Ternary Coordination Compounds of Copper(II) with Glycine and 2,2'-bipyridine: Synthesis, Structural Characterization, Magnetic and Biological Properties. Croatica Chemica Acta, 95 (4). pp. 157-165. ISSN 0011-1643

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Abstract

Three new coordination compounds of copper(II) with glycine (HGly) and 2,2'-bipyridine (bipy) were synthesized by solution-based and mechanochemical methods: [Cu(Gly)(H2O)(bipy)][Cu(Gly)(SO4)(bipy)]·6H2O (1a·6H2O), [Cu(Gly)(H2O)(bipy)]2SO4 (1b), [Cu(Gly)(H2O) (bipy)]2SO4·H2O (1b·H2O). The amount of water in the reaction mixture influenced the product of crystallization. All compounds were characterized by X-ray diffraction methods and form 1D infinite chains or 2D sheets of complex ions connected by π-interactions. Compounds 1a·6H2O and 1b were characterized by X-band electron spin resonance (ESR) spectroscopy and the values of g-tensors for Cu(II) ions were determined. Compounds 1a·6H2O and 1b showed pronounced antiproliferative activity toward a panel of six human cell lines. The most impared was HepG2 cell line at 10−5 mol dm−3 concentration (74.5 % reduction of cell growth) followed by moderate activity toward KATO III, Caco-2, MDA-MB-231, PANC-1 and MRC-5 cells at 10−4 mol dm−3 concentration of compounds 1a·6H2O and 1b. Generally, both compounds express similar antiproliferative effect on evaluated cells.

Item Type:	Article
Uncontrolled Keywords:	X-ray diffraction; ESR spectroscopy; crystallization; mechanochemistry; ternary coordination compounds; copper(II); glycine; carcinoma; tumor cell lines
Subjects:	NATURAL SCIENCES > Chemistry > Physical Chemistry NATURAL SCIENCES > Chemistry > Inorganic Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Studija važnosti spinskih međudjelovanja kao osnova za nove pristupe u istraživanju materijala-SPES Marina Ilakovac-Kveder IP-2018-01-3168 HRZZ Razvoj održivog integriranog procesa proizvodnje biološki aktivnih izolata iz proizvodnih ostataka prehrambene industrije-POPI-WinCEco Ana Bucić-Kojić IP-2018-01-1227 HRZZ
Depositing User:	Lorena Palameta
Date Deposited:	15 Jul 2026 08:43
URI:	https://fulir.irb.hr:/id/eprint/12072
DOI:	10.5562/cca3936

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