Special Issue “Mechanism of Enzyme Catalysis: When Structure Meets Function”

Leščić Ašler, Ivana (2026) Special Issue “Mechanism of Enzyme Catalysis: When Structure Meets Function”. International Journal of Molecular Sciences, 27 (4). ISSN 1422-0067

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Abstract

While genome DNA can be called “a blueprint for life”, the realization of this blueprint is the responsibility of proteins. There is no doubt that the function of proteins and, more specifically, enzymes is intimately linked with their three-dimensional structure. With the development of the artificial intelligence (AI) tool Alpha Fold for the prediction of a protein’s 3D structure, a breakthrough occurred enabling bridging the gap between the numbers of known enzyme sequences, available 3D structures, and functionally characterized enzymes. However, in order to characterize an enzyme sufficiently, its structure and function have to be investigated in detail, using a multidisciplinary approach, collecting the knowledge from all possible sides, thus making old-fashioned biochemistry and functional studies far from redundant. Following this line of thought, this Special Issue has collected 10 original research articles and 4 review articles that investigate the function and mechanism of action of different enzymes.

Item Type:	Article
Uncontrolled Keywords:	enzymes; structure; function
Subjects:	NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions:	Division of Physical Chemistry
Depositing User:	Ana Zečević
Date Deposited:	06 May 2026 18:12
URI:	https://fulir.irb.hr:/id/eprint/11922
DOI:	10.3390/ijms27041887

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