Filipić, Brankica; Pantelić, Ivana; Nikolić, Ines; Majhen, Dragomira; Stojić-Vukanić, Zorica; Savić, Snežana; Krajišnik, Danina (2023) Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines. Vaccines, 11 (7). ISSN 2076-393X
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Abstract
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases.
| Item Type: | Article | ||||||||||||
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| Uncontrolled Keywords: | nanoadjuvants; nanoemulsions; viral-vectored system; virus-like particles | ||||||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences | ||||||||||||
| Divisions: | Division of Molecular Biology | ||||||||||||
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| Depositing User: | Josipa Karadžole | ||||||||||||
| Date Deposited: | 30 Apr 2026 09:56 | ||||||||||||
| URI: | https://fulir.irb.hr:/id/eprint/11846 | ||||||||||||
| DOI: | 10.3390/vaccines11071172 |
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