Pešut, Ena; Đukić, Anamaria; Lulić, Lucija; Skelin, Josipa; Šimić, Ivana; Gašperov, Nina Milutin; Tomaić, Vjekoslav; Sabol, Ivan; Grce, Magdalena (2021) Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge. Viruses-Basel, 13 (11). ISSN 1999-4915
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Abstract
Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, including Croatia, and worldwide. Nowadays, the causative role of a subset of oncogenic or high-risk (HR) HPV types, led by HPV-16 and HPV-18, of different anogenital and head and neck cancers is well accepted. Two major viral oncoproteins, E6 and E7, are directly involved in the development of HPV-related malignancies by targeting synergistically various cellular pathways involved in the regulation of cell cycle control, apoptosis, and cell polarity control networks as well as host immune response. This review is aimed at describing the key elements in HPV-related carcinogenesis and the advances in cancer prevention with reference to past and ongoing research in Croatia
| Item Type: | Article | ||||||||||||||||
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| Uncontrolled Keywords: | human papillomaviruses (HPV) ; oncoproteins ; proteomics ; epigenetics ; biomarkers ; cancer ; therapeutics ; immunology | ||||||||||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Gynecology and Obstetrics BIOMEDICINE AND HEALTHCARE > Public Health and Health Care > Epidemiology |
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| Divisions: | Division of Molecular Medicine | ||||||||||||||||
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| Depositing User: | Ivan Sabol | ||||||||||||||||
| Date Deposited: | 11 Nov 2021 08:34 | ||||||||||||||||
| URI: | http://fulir.irb.hr/id/eprint/6597 | ||||||||||||||||
| DOI: | 10.3390/v13112234 |
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