Cancer drug resistance induced by EMT: novel therapeutic strategies

De Las Rivas, Javier; Brozović, Anamaria; Izraely, Sivan; Casas-Pais, Alba; Witz IP, Figueroa (2021) Cancer drug resistance induced by EMT: novel therapeutic strategies. Archives of toxicology, 95 . pp. 2279-2297. ISSN 0340-5761

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Abstract

Over the last decade, important clinical benefits have been achieved in cancer patients by using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in most cancer therapies. Epithelial-mesenchymal plasticity (EMP) and tumour microenvironment have been described as limiting factors for effective treatment in many cancer types. Moreover, epithelial-to-mesenchymal transition (EMT) has also been associated with therapy resistance in many different preclinical models, although limited evidence has been obtained from clinical studies and clinical samples. In this review, we particularly deepen into the mechanisms of which intermediate epithelial/mesenchymal (E/M) states and its interconnection to microenvironment influence therapy resistance. We also describe how the use of bioinformatics and pharmacogenomics will help to figure out the biological impact of the EMT on drug resistance and to develop novel pharmacological approaches in the future.

Item Type:	Article
Uncontrolled Keywords:	Epithelial plasticity ; Cancer ; Therapy resistance ; Tumor microenvironmen
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika Brozović, Anamaria IP-2016-06-1036 HRZZ
Depositing User:	Anamaria Brozović
Date Deposited:	08 Jul 2021 12:21
URI:	http://fulir.irb.hr/id/eprint/6491
DOI:	10.1007/s00204-021-03063-7

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