The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside

Meštrović, Tomislav; Matijašić, Mario; Perić, Mihaela; Čipčić Paljetak, Hana; Barešić, Anja; Verbanac, Donatella (2020) The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside. Diagnostics, 11 (1). ISSN 2075-4418

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Official URL: https://www.mdpi.com/2075-4418/11/1/7

Abstract

The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the contamination of the periurethral space by specific uropathogens residing in the gut, which is followed by urethral colonization and pathogen ascension to the urinary bladder. Consequently, studying the relationship between gut microbiota and the subsequent development of bacteriuria and UTI represents an important field of research. However, the well-established diagnostic and therapeutic paradigm for urinary tract infections (UTIs) has come into question with the discovery of a multifaceted, symbiotic microbiome in the healthy urogenital tract. More specifically, emerging data suggest that vaginal dysbiosis may result in Escherichia coli colonization and prompt recurrent UTIs, while urinary microbiome perturbations may precede the development of UTIs and other pathologic conditions of the urinary system. The question is whether these findings can be exploited for risk reduction and treatment purposes. This review aimed to appraise the three aforementioned specific microbiomes regarding their potential influence on UTI development by focusing on the recent studies in the field and assessing the potential linkages between these different niches, as well as evaluating the state of translational research for novel therapeutic and preventative approaches.

Item Type:

Article

Uncontrolled Keywords:

microbiome ; microbiota ; gut microbiome ; vaginal microbiome ; urobiome ; urinary tract ; urinary tract infection ; UTI ; bacteriuria ; dysbiosis

Subjects:

NATURAL SCIENCES > Biology

Divisions:

Division of Electronics

Projects:

Project title	Project leader	Project code	Project type
Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva	Verbanac, Donatella	IP-2013-11-5467	HRZZ

Depositing User:

Anja Barešić

Date Deposited:

14 May 2021 06:52

URI:

http://fulir.irb.hr/id/eprint/6410

DOI:

10.3390/diagnostics11010007