In vivo and in vitro models in diabetes research

Popović Hadžija, Marijana; Antonić, Tatjana In vivo and in vitro models in diabetes research. In: Laboratory animals in scientific research. p. 28 .

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Abstract

Diabetes is one of the major health problems worldwide with rapidly growing incidence. It is progressive disease characterized by the inability to produce or/and properly use insulin. Regardless of medical treatment, diabetic patients as well as animals have recurring episodes of hyperglycemia that permit the development of diabetic complications. Episodes of hyperglycemia after eating are particularly harmful. It was known that glucose, resulting from digestive process, goes across intestinal membrane and is absorbed in the blood stream. Partial reduction of glucose uptake in small intestine of diabetic organism might prevent hyperglycemia-induced stress and the development of diabetic complications. The use of in vivo and in vitro models in studying disease is fundamental to the advancement of understanding of mechanisms, disease dysfunctions and development and testing of therapeutics. The presentation will be focused on mouse models, which we have used in research with the special accent on a new method for analysis of diabetic/control urine. Also, we will present our preliminary results observed by using Caco-2 cell line. Namely, human intestinal cells have been extensively used to study absorption and intestinal physiology. Thereby, our attention will be focused on the investigation of reducing glucose uptake after cell treatment with Ca Zeolite A.

Item Type:	Conference or workshop item published in conference proceedings (UNSPECIFIED)
Uncontrolled Keywords:	diabetes; mouse; hyperglycemia; Caco-2 cell
Subjects:	INTERDISCIPLINARY AREAS OF KNOWLEDGE > Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Divisions:	Division of Materials Chemistry Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Sirtuin3 kao posrednik mitohondrijske funkcije u estrogen-ovisnoj otpornosti na oksidativni stres i prehranu s visokim udjelom masti-SuMERA Tihomir Balog IP-2014-09-4533 HRZZ Sinteza naprednih anorganskih katalizatora s povećanim brojem kiselih mjesta-SAdInCat Josip Bronić IP-2016-06-2214 HRZZ
Depositing User:	Marijana Popović Hadžija
Date Deposited:	13 Nov 2018 12:51
URI:	http://fulir.irb.hr/id/eprint/4235

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