The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

Pivac, Nela; Kozarić-Kovačić, Dragica; Grubišić-Ilić, Mirjana; Nedić, Gordana; Rakoš, Iva; Nikolac, Matea; Blažev, Martina; Muck-Šeler, Dorotea (2012) The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder. The world journal of biological psychiatry, 13 (4). pp. 306-311. ISSN 1562-2975

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Official URL: http://www.tandfonline.com/doi/abs/10.3109/1562297...

Abstract

Objective: Psychotic symptoms frequently occur in veterans with combat-related posttraumatic stress disorder (PTSD). Brain-derived neurotrophic factor (BDNF) plays a major role in neurodevelopment, neuro-regeneration, neurotransmission, learning, regulation of mood and stress responses. The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. This study intended to assess whether the Met allele is overrepresented in unrelated Caucasian male veterans with psychotic PTSD compared to veteran controls. Method: The BDNF Val66Met variants were genotyped in 576 veterans: 206 veterans without PTSD and 370 veterans with PTSD subdivided into groups with or without psychotic features. Results: Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD. Conclusions: The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD.

Item Type:

Article

Uncontrolled Keywords:

BDNF; polymorphism; PTSD; psychosis; veterans

Subjects:

BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences

Divisions:

Division of Molecular Medicine

Projects:

Project title	Project leader	Project code	Project type
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-	Nela Pivac	098-0982522-2455	MZOS
Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)-	Dorotea Muck-Šeler	098-0982522-2457	MZOS
Psychophysiology in the diagnosis of stress-induced disorders (Psihofiziološka dijagnostika poremećaja uzrokovanih stresom)-	Dragica Kozarić-Kovačić	198-0982522-0075	MZOS
The effect of lipid status, homocisteine and oLAB on cognitive function in PTSD (Utjecaj lipidnog statusa, homocisteina i oLAB-a na kognitivne funkcije u PTSP-u)-	Davor Rak	198-1081870-0074	MZOS