The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence

Nikolac, Matea; Šagud, Marina; Nedić, Gordana; Nenadić Šviglin, Korona; Mihaljević Peleš, Alma; Uzun, Suzana; Vuskan Čusa, Bjanka; Kozumplik, Oliver; Živković, Maja; Mustapić, Maja; Jakovljević, Miro; Pavlović, Mladen; Muck-Šeler, Dorotea; Borovečki, Fran; Pivac, Nela (2013) The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence. Psychiatry Research, 205 (1/2). pp. 179-180. ISSN 0165-1781

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Abstract

The study elucidated the association between the COMT Val108/158Met polymorphism and smoking in patients with schizophrenia, patients with alcohol dependence and healthy control subjects. The stepwise logistic regression (odds ratio (OR)=1.56, 95% confidence interval (CI)=1.10–2.23, P=0.014) and the χ2 test (P=0.008) revealed that the COMT Val/Val genotype was significantly associated with smoking in healthy male subjects. Although the hypothesis of the study was that COMT Val108/158Met genotypes will be significantly associated with smoking in schizophrenia and alcohol dependence, our study showed for the first time the lack of significant association between smoking and COMT Val108/158Met polymorphism in schizophrenia, and confirmed no association between smoking and COMT Val108/158Met in alcoholism.

Item Type:

Article

Uncontrolled Keywords:

catechol-O-methyltransferase (COMT); shizophrenia; alcohol dependence; smoking; association study

Subjects:

BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences

Divisions:

Division of Molecular Medicine

Projects:

Project title	Project leader	Project code	Project type
Genomic Analysis of Transcriptome and Interactome in Complex Disease Patients (Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima)-	Fran Borovečki	108-1081874-1923	MZOS
Pharmacogenetic varability of psychiatric patients (Farmakogenetska varijabilnost u psihijatrijskih bolesnika)-	Alma Mihaljević-Peleš	108-1083509-3513	MZOS
Side effects of psychopharmacs in patients with psychosis and mood disorders (Nuspojave psihofarmaka u bolesnika s psihotičnim i afektivnim poremećajima)-	Suzana Uzun	108-1083509-3511	MZOS
Multidimensional analysis of bilogical markers in mental disorders (Multidimenzionalna analiza bioloških pokazatelja u duševnim poremećajima)-	Miro Jakovljević	108-1080037-0323	MZOS
BIOLOGICAL MARKERS OF ACTIVITY OF ELECTROMAGNETIC NONIONIZING RADIATION (BIOLOŠKI POKAZATELJI DJELOVANJA ELEKTROMAGNETSKOG NEIONIZIRAJUĆEG ZRAČENJA)-	Ivančica Trošić	022-0222411-2406	MZOS
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-	Nela Pivac	098-0982522-2455	MZOS
Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)-	Dorotea Muck-Šeler	098-0982522-2457	MZOS