Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes

Mirosavljević, Krunoslav; Matković, Marija; Mlinarić-Majerski, Kata; Noethig-Laslo, Vesna (2014) Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes. Croatica chemica acta, 87 (3). pp. 249-253. ISSN 0011-1643

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Abstract

Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride (compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dynamics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggested that both adamantyl compounds influenced molecular motions in the interfacial region of the liposome. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamellar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydrophobic core as well.

Item Type:	Article
Uncontrolled Keywords:	adamantyl compounds; drug transport; drug interactions; physicochemical properties; spin labelling; ESR; spectroscopy; liposomes; phospholipids
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima [27342] Kata Majerski 098-0982933-2911 MZOS Molekulska struktura i dinamika sustava s paramagnetskim česticama Marina Ilakovac-Kveder 098-0982915-2939 MZOS
Depositing User:	Sofija Konjević
Date Deposited:	05 Mar 2015 13:49
URI:	http://fulir.irb.hr/id/eprint/1706
DOI:	10.5562/cca2399

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