First hydroxamic seconucleoside derivatives

Vrček, Valerije; Čaplar, Vesna; Uršić, Stanko (1998) First hydroxamic seconucleoside derivatives. Croatica Chemica Acta, 71 (1). pp. 119-124. ISSN 0011-1643

PDF - Published Version Download (69kB)

Abstract

Nucleoside analogues possessing hydroxamate moiety were prepared from secouridine derivatives oxidized at C(2')-position. 3',5'-O-Isopropylidene-2',3'-secouridine was oxidized with CrO3/py complex to the carboxylate level and with DMSO/DCC to the aldehyde level. Both compounds (precursors) gave C(2')-nucleoside hydroxamic acids in the reaction with hydroxylamine or nitrosobenzene in the presence of Fe3+ ions, respectively.

Item Type:	Article
Uncontrolled Keywords:	coli ribonucleotide reductase; escherichia-coli; virus type-1; inhibition; hydroxyurea; cells; acids; replication; subunit; analogs
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Interakcije nitrozospojeva s biomedicinski važnim molekulama Stanko Uršić 006142 MZOS Mehanizam reakcije stvaranja steroidnih spojeva Olga Kronja 006151 MZOS Projektiranje i sinteza supramolekularnih sustava Mladen Žinić 00980703 MZOS
Depositing User:	Vesna Čaplar
Date Deposited:	28 Nov 2013 11:38
URI:	http://fulir.irb.hr/id/eprint/1163

Actions (login required)

View Item