Deuteration of Pd-activated C(sp2)-H bonds in the solid state

Bjelopetrović, Alen; Barišić, Dajana; Juribašić Kulcsar, Marina; Halasz, Ivan; Ćurić, Manda; Lukin, Stipe (2023) Deuteration of Pd-activated C(sp2)-H bonds in the solid state. Inorganic Chemistry Frontiers, 10 (20). pp. 6005-6014. ISSN 2052-1553

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Abstract

We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp2)–H bonds at ambient temperature under solvent-free conditions. Deuterium was sourced from cysteine-d4 to obtain mono- or dideuterated products from various aromatic palladacycles. Next to good deuteration yields, based on time-resolved in situ Raman monitoring and DFT calculations, we present a detailed view of the reaction course in the solid state. The obtained knowledge could lead to the broader application of this methodology for the deuteration of organics.

Item Type:	Article
Uncontrolled Keywords:	deuteration; calculations; palladium; Raman spectroscopy; solid-state reaction
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Mehanokemijska aktivacija i funkcionalizacija veze C–H potaknuta paladijem i usmjerena ligandom-MECHEMFUN Manda Ćurić IP-2019-04-9951 HRZZ Sistematika mehanizama u bezotopinskoj ili tekućinski kataliziranoj sintezi u čvrstom stanju-SystForSynt Ivan Halasz IP-2020-02-1419 HRZZ
Depositing User:	Senada Muratović
Date Deposited:	13 Feb 2025 10:33
URI:	http://fulir.irb.hr/id/eprint/9566
DOI:	10.1039/D3QI00932G

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