Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia

Nikolac Perković, Matea; Borovečki, Fran; Filipčić, Igor; Vuić, Barbara; Miloš, Tina; Nedić Erjavec, Gordana; Konjevod, Marcela; Tudor, Lucija; Mimica, Ninoslav; Uzun, Suzana; Kozumplik, Oliver; Švob Štrac, Dubravka; Pivac, Nela (2023) Relationship between Brain-Derived Neurotrophic Factor and Cognitive Decline in Patients with Mild Cognitive Impairment and Dementia. Biomolecules, 13 (3). ISSN 2218-273X

PDF - Published Version - article Available under License Creative Commons Attribution. Download (854kB)

Abstract

In the last decade, increasing evidence has emerged linking alterations in the brain-derived neurotrophic factor (BDNF) expression with the development of Alzheimer’s disease (AD). Because of the important role of BDNF in cognition and its association with AD pathogenesis, the aim of this study was to evaluate the potential difference in plasma BDNF concentrations between subjects with mild cognitive impairment (MCI ; N = 209) and AD patients (N = 295) and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed a significantly higher (p < 0.001) concentration of plasma BDNF in subjects with AD (1.16 ; 0.13–21.34) compared with individuals with MCI (0.68 ; 0.02–19.14). The results of the present study additionally indicated a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline. The correlation analysis revealed a significant negative correlation between BDNF plasma levels and both Mini-Mental State Examination (p < 0.001) and Clock Drawing test (p < 0.001) scores. In conclusion, the results of our study point towards elevated plasma BDNF levels in AD patients compared with MCI subjects, which may be due to the body’s attempt to counteract the early and middle stages of neurodegeneration.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer’s disease (AD); brain-derived neurotrophic factor (BDNF); Clock Drawing test (CDT); mild cognitive impairment (MCI); Mini-Mental State Examination (MMSE)
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Terapijski potencijal neurosteroida i neurotrofina u demenciji-TePoNeDe Dubravka Švob Štrac; Ninoslav Mimica; Suzana Uzun; Oliver Kozumplik; Julija Erhardt; Ana-Marija Domijan; Dora Zelena; Erika Pinter; Coral Barbas IP-2019-04-6100 HRZZ Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja- Nela Pivac 098-0982522-2455 MZOS
Depositing User:	Matea Nikolac Perković
Date Deposited:	08 Jan 2025 08:32
URI:	http://fulir.irb.hr/id/eprint/9384
DOI:	10.3390/biom13030570

Actions (login required)

View Item