Clinician’s Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer

Kvolik Pavić, Ana; Čonkaš, Josipa; Mumlek, Ivan; Zubčić, Vedran; Ozretić, Petar (2024) Clinician’s Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer. Life, 14 (10). ISSN 2075-1729

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Abstract

Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible. A specific group of enzymes called “writers” introduces the change to the RNA; “erasers” delete it, while “readers” stimulate a downstream effect. Epitranscriptomic changes are present in every type of organism from single-celled ones to plants and animals and are a key to normal development as well as pathologic processes. Oncology is a fast-paced field, where a better understanding of tumor biology and (epi)genetics is necessary to provide new therapeutic targets and better clinical outcomes. Recently, changes to the epitranscriptome have been shown to be drivers of tumorigenesis, biomarkers, and means of predicting outcomes, as well as potential therapeutic targets. In this review, we aimed to give a concise overview of epitranscriptomics in the context of neoplastic disease with a focus on N1-methyladenosine (m1A) modification, in layman’s terms, to bring closer this omics to clinicians and their future clinical practice.

Item Type:	Article
Uncontrolled Keywords:	epitranscriptomics; RNA modifications; m1A; reader; writer; eraser; cancer
Subjects:	NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Human Genetics, Genomics and Proteomics
Divisions:	Division of Molecular Medicine
Depositing User:	Lorena Palameta
Date Deposited:	03 Oct 2024 11:09
URI:	http://fulir.irb.hr/id/eprint/9101
DOI:	10.3390/life14101230

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