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Protein induced lipid demixing in homogeneous membranes

Stumpf, Bernd Henning; Nowakowski, Piotr; Eggeling, Christian; Maciołek, Anna; Smith, Ana-Sunčana (2021) Protein induced lipid demixing in homogeneous membranes. Physical Review Research, 3 (4). ISSN 2643-1564

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Specific lipid environments are necessary for the establishment of protein signaling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model of protein induced local demixing of lipid membranes. The coupling between a local composition and a local thickness of the membrane induces lipid domains around inclusions with hydrophobic mismatch, even for temperatures above the miscibility critical point of the membrane. The model qualitatively explains the experimentally observed formation of lipid domains induced by anchoring of reconstituted actin in flat supported lipid bilayers.

Item Type: Article
Uncontrolled Keywords: homogeneous membranes; lipid; demixing; protein
Subjects: NATURAL SCIENCES > Physics
Divisions: Division of Physical Chemistry
Depositing User: Ana Zečević
Date Deposited: 14 Mar 2024 08:44
DOI: 10.1103/PhysRevResearch.3.L042013

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