Solvent effects on the crystallization and structure of ternary copper(ii) coordination compounds with l-threonine and 1,10-phenanthroline

Vušak, Darko; Ležaić, Katarina; Jurec, Jurica; Žilić, Dijana; Prugovečki, Biserka (2022) Solvent effects on the crystallization and structure of ternary copper(ii) coordination compounds with l-threonine and 1,10-phenanthroline. Heliyon, 8 (6). ISSN 24058440

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Abstract

Solution-based and solid-state reactions of copper(ii) compounds, 1,10-phenanthroline and l-threonine were investigated. Eight new ternary coordination compounds were obtained: [Cu(l-Thr)(H2O)(phen)]2SO4∙10H2O (1a∙10H 2 O), [Cu(l-Thr)(H2O) (phen)]2SO4∙4.3H2O (1a∙4.3H 2 O), {[Cu(μ-l-Thr)(phen)]2SO4∙3.5H2O} n (1b∙3.5H 2 O), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)]SO4∙2H2O∙CH3OH (1c∙2H 2 O∙CH 3 OH), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)]SO4∙4H2O (1c∙4H 2 O), [Cu(l-Thr)(CH3OH)(phen)]2SO4∙H2O (1d∙H 2 O), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)][Cu(SO4)(l-Thr)(phen)]HSO4∙H2O∙3CH3OH (1e·H 2 O·3CH 3 OH), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(phen)(py)]SO4 (1f) (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the dx2-y2 orbital which is in agreement with elongated square-pyramidal geometry. Compound 1a∙10H 2 O showed substantial cytotoxic activity toward human hepatocellular carcinoma (HepG2) and acute monocytic leukaemia (THP-1) cell lines.

Item Type:	Article
Uncontrolled Keywords:	1,10-Phenanthroline; Copper complexes; Crystal structures; ESR spectra; Mechanochemical synthesis; Solution-based synthesis; Solvatomorphs; Ternary coordination compounds; l-threonine
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Studija važnosti spinskih međudjelovanja kao osnova za nove pristupe u istraživanju materijala Marina Ilakovac Kveder IP-2018-01-3168 Znanstveno-istraživački projekti Centar izvrsnosti u kemiji - CIuK Josip Požar KK.01.1.1.02.0016 Infrastrukturni projekti
Depositing User:	Diana Mikoč Radešić
Date Deposited:	24 Jan 2024 14:50
URI:	http://fulir.irb.hr/id/eprint/8374
DOI:	10.1016/j.heliyon.2022.e09556

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