hrvatski jezikClear Cookie - decide language by browser settings

CD and FTIR Spectroscopic Studies of Carbohydrate-modified Opioid Peptides

Vass, Elmer; Hollosi, Miklos; Horvat, Štefica; Roščić, Maja (2008) CD and FTIR Spectroscopic Studies of Carbohydrate-modified Opioid Peptides. Croatica Chemica Acta, 81 (4). pp. 647-656. ISSN 0011-1643

[img] PDF - Published Version
Download (301kB)


The variety of vital functions played by glycoproteins in many physiological and pathological processes inspired the design of glycopeptides and the study of the effect of glycosylation on conformation. This work reports comparative circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopic studies on linear and cyclic Amadori and imidazolidinone-type glycopeptides 3-8 in comparison with spectroscopic data of the non-modified flexible parent peptides, Leu-enkephalin (H-Tyr-Gly-Gly-Phe-Leu-OH. 1) and its amide (H-Tyr-Gly-Gly-Phe-Leu-NH, 2). The CD and FTIR measurements were performed in different solvents in order to expose the structural and conformational differences caused by a keto-sugar. a rigid 5-membered imidazolidinone ring and/or cyclization. The combined application of CD and MR spectroscopy allowed to evaluate the relative amount of the extended and folded conformers of Amadori as well as imidazolidinone compounds and proved to be an effective tool for characterization of their structural features leading to a deeper understanding of their conformational behaviour.

Item Type: Article
Uncontrolled Keywords: glycopeptides; Amadori; imidazolidinone; conformational analysis; circular dichroism; IR spectroscopy; circular-dichroism spectra; optical-activity; protein glycosylation; leucine-enkephalin; maillard reaction; nmr; sugars; brain; 4-imidazolidinones; identification
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Kemijske preobrazbe prirodnih spojeva[16092] Lidija Varga-Defterdarović098-0982933-2936MZOS
Depositing User: Štefica Horvat
Date Deposited: 22 Oct 2013 13:23

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font