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Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential

Vuić, Barbara; Miloš, Tina; Tudor, Lucija; Konjevod, Marcela; Nikolac Perković, Matea; Jazvinšćak Jembrek, Maja; Nedić Erjavec, Gordana; Švob Štrac, Dubravka (2022) Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines, 10 (12). ISSN 2227-9059

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Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems and subsequently lead to chronic neuroinflammation that drives the onset and progression of neurodegenerative diseases. Since there is still no effective disease- modifying treatment, new therapeutic targets for neurodegenerative proteinopathies have been sought. The endocannabinoid system, and in particular the cannabinoid CB2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. Several studies have shown promising effects of CB2 receptor activation on reducing protein aggregationbased pathology as well as on attenuating inflammation and several dementia- related symptoms. In this review, we discuss the available data on the role of CB2 receptors in neuroinflammation and the potential benefits and limitations of specific agonists of these receptors in the therapy of neurodegenerative proteinopathies.

Item Type: Article
Uncontrolled Keywords: neurodegenerative diseases ; proteinopathies ; endocannabinoid system ; cannabinoid CB2 receptors ; neuroinflammation ; therapy
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Gordana Nedić Erjavec
Date Deposited: 03 Apr 2023 10:36
DOI: 10.3390/biomedicines10123000

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