The Arg72Pro Polymorphism of TP53 in Croatian Population

Zorić, Arijana; Horvat, Anđela; Balija, Melita; Slade, Neda (2012) The Arg72Pro Polymorphism of TP53 in Croatian Population. Croatica Chemica Acta, 85 (2). pp. 239-243. ISSN 0011-1643

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Abstract

Single nucleotide polymorphisms of TP53 gene in human populations are expected to cause perturbation of p53 function, and therefore could influence risk and/or progress of disease. There are differences in inducing apoptosis, cell cycle arrest, transcriptional activity, protein interactions between variants in codon 72 (Arg72Pro), although the association of polymorphism and risk of cancer is controversial. The aim of our study was to investigate the frequency of alleles and genotypes of Arg72Pro polymorphism in the ethnically homogenous Croatian population and to compare it with the worldwide populations. In a cohort of 576 participants the genotype frequencies of Arg/Arg, Arg/Pro and Pro/Pro are 54.34, 38.71 and 6.95 %, respectively. We statistically sorted the population of Croatia into the same group with other European populations and Caucasians from North America. This finding is important for the molecular pathways studies involved in disease as well as in pharmacogenetic studies.

Item Type:	Article
Uncontrolled Keywords:	tumor suppressor gene p53; p73; SNP; Arg72Pro; codon 72 polymorphism; cervical-cancer; p53 polymorphism; lung-cancer; human-papillomavirus; breast-cancer; risk; variants; association; mutations
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka [173221] Neda Slade 098-0982464-2391 MZOS
Depositing User:	Neda Slade
Date Deposited:	14 Oct 2013 09:50
URI:	http://fulir.irb.hr/id/eprint/781
DOI:	10.5562/cca1866

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