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Can Differently Stabilized Silver Nanoparticles Modify Calcium Phosphate Precipitation?

Inkret, Suzana; Ćurlin, Marija; Smokrović, Kristina; Kalčec, Nikolina; Peranić, Nikolina; Maltar-Strmečki, Nadica; Domazet Jurašin, Darija; Dutour Sikirić, Maja (2023) Can Differently Stabilized Silver Nanoparticles Modify Calcium Phosphate Precipitation?. Materials, 16 (5). ISSN 1996-1944

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Calcium phosphates (CaPs) composites with silver nanoparticles (AgNPs) attract attention as a possible alternative to conventional approaches to combating orthopedic implant-associated infections. Although precipitation of calcium phosphates at room temperatures was pointed out as an advantageous method for the preparation of various CaP-based biomaterials, to the best of our knowledge, no such study exists for the preparation of CaPs/AgNP composites. Motivated by this lack of data in this study we investigated the influence of AgNPs stabilized with citrate (cit-AgNPs), poly(vinylpyrrolidone) (PVP-AgNPs), and sodium bis(2-ethylhexyl) sulfosuccinate (AOT- AgNPs) in the concentration range 5–25 mg dm−3 on the precipitation of CaPs. The first solid phase to precipitate in the investigated precipitation system was amorphous calcium phosphate (ACP). The effect of AgNPs on ACP stability was significant only in the presence of the highest concentration of AOT-AgNPs. However, in all precipitation systems containing AgNPs, the morphology of ACP was affected, as gel-like precipitates formed in addition to the typical chain-like aggregates of spherical particles. The exact effect depended on the type of AgNPs. After 60 min of reaction time, a mixture of calcium-deficient hydroxyapatite (CaDHA) and a smaller amount of octacalcium phosphate (OCP) formed. PXRD and EPR data point out that the amount of formed OCP decreases with increasing AgNPs concentration. The obtained results showed that AgNPs can modify the precipitation of CaPs and that CaPs properties can be fine-tuned by the choice of stabilizing agent. Furthermore, it was shown that precipitation can be used as a simple and fast method for CaP/AgNPs composites preparation which is of special interest for biomaterials preparation.

Item Type: Article
Uncontrolled Keywords: calcium phosphates ; silver nanoparticles ; amorphous calcium phosphate ; transformation ; composites
Subjects: NATURAL SCIENCES > Physics
Divisions: Division of Physical Chemistry
Project titleProject leaderProject codeProject type
Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkivaDutour Sikirić, MajaIP-2018-01-1493HRZZ
Depositing User: Nadica Maltar Strmečki
Date Deposited: 03 Apr 2023 13:13
DOI: 10.3390/ma16051764

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