Satellite DNAs in Health and Disease

Ugarković, Đurđica; Sermek, Antonio; Ljubić, Sven; Feliciello, Isidoro (2022) Satellite DNAs in Health and Disease. Genes, 13 . ISSN 2073-4425

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Official URL: https://www.mdpi.com/2073-4425/13/7/1154

Abstract

Tandemly repeated satellite DNAs are major components of centromeres and pericentromeric heterochromatin which are crucial chromosomal elements responsible for accurate chromosome segregation. Satellite DNAs also contribute to genome evolution and the speciation process and are important for the maintenance of the entire genome inside the nucleus. In addition, there is increasing evidence for active and tightly regulated transcription of satellite DNAs and role for their transcripts in diverse processes. In this review, we focus on recent discoveries related to the regulation of satellite DNA expression and the role of their transcripts either in heterochromatin establishment and centromere function or in gene expression regulation under various biological contexts. We discuss the role of satellite transcripts in the stress response and environmental adaptation as well as consequences of dysregulation of satellite DNA expression in cancer and their potential use as cancer biomarkers.

Item Type:

Article

Uncontrolled Keywords:

satellite DNA ; heterochromatin ; satellite RNA ; epigenetics ; heat stress ; cancer ; biomarker

Subjects:

NATURAL SCIENCES > Biology

Divisions:

Division of Molecular Biology

Projects:

Project title	Project leader	Project code	Project type
Alfa satelitska DNA u evoluciji mreža genske modulacije-AlphaSatGenNet	Đurđica Ugarković; Dušan Kordiš; Jure Skejić; Antonio Sermek	IP-2019-04-6915	HRZZ

Depositing User:

Đurđica Ugarković

Date Deposited:

17 Oct 2022 12:13

URI:

http://fulir.irb.hr/id/eprint/7587

DOI:

10.3390/genes13071154