Beljan, Silvestar; Herak Bosnar, Maja; Ćetković, Helena (2020) Rho Family of Ras-Like GTPases in Early-Branching Animals. Cells, 9 (10). ISSN 2073-4409
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Abstract
Non-bilaterian animals consist of four phyla ; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho- family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | non-bilaterian animals ; Rho GTPases ; Cdc24 ; Rho ; Rac ; RhoBTB ; Miro ; Porifera ; Ctenophora ; Placozoa ; Cnidaria | ||||||||
| Subjects: | NATURAL SCIENCES > Biology NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Helena Ćetković | ||||||||
| Date Deposited: | 25 Aug 2022 08:17 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/7522 | ||||||||
| DOI: | 10.3390/cells9102279 |
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