hrvatski jezikClear Cookie - decide language by browser settings

Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD

Repovečki, Senka; Nedić Erjavec, Gordana; Uzun, Suzana; Tudor, Lucija; Nikolac Perković, Matea; Konjevod, Marcela; Kozumplik, Oliver; Švob Štrac, Dubravka; Kovačić Petrovic, Zrnka; Mimica, Ninoslav; Pivac, Nela (2022) Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Biomolecules, 12 (5). ISSN 2218-273X

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (842kB) | Preview


Post‐traumatic stress disorder (PTSD) is a trauma‐related disorder. Platelet monoamine oxidase (MAO‐B) is a peripheral biomarker associated with various symptoms in different psychopathologies, but its role in PTSD or different symptoms in PTSD is not clear. This study elucidated the association between platelet MAO‐B activity and clinical symptoms occurring in PTSD. Platelet MAO‐B activity was determined in 1053 male Caucasian subjects: 559 war veterans with PTSD (DSM‐5 criteria), 62 combat exposed veterans who did not develop PTSD, and 432 non‐combat exposed healthy controls. Clinical symptoms in PTSD were determined using CAPS and PANSS. Platelet MAO‐B activity, controlled for the effect of smoking, was significantly increased in PTSD with severe versus mild and moderate traumatic symptoms, and was significantly decreased in PTSD subjects with severe versus mild positive, psychotic, and depressive symptoms. This finding was further confirmed with reduced platelet MAO‐B activity in PTSD veterans with severe versus mild individual items of the PANSS‐depressed, PANSS‐psychotic, and PANSS‐positive subscales. Altered platelet MAO‐B activity, controlled for the possible confounders, was associated with the development and severity of different symptoms occurring in PTSD. These findings confirmed the role of platelet MAO‐B activity as a peripheral marker of various psychopathological symptoms.

Item Type: Article
Uncontrolled Keywords: PTSD ; platelet MAO‐B activity ; clinical symptoms ; PANSS ; CAPS
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Gordana Nedić Erjavec
Date Deposited: 30 Jun 2022 08:58
DOI: 10.3390/biom12050736

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font