Stereochemistry of 2,2'-iminodiacetamide and bis(2-pyridine-2-ylmethyl)amine complexes and their application in enantioselective catalysis

Pantalon Juraj, Natalija (2021) Stereochemistry of 2,2'-iminodiacetamide and bis(2-pyridine-2-ylmethyl)amine complexes and their application in enantioselective catalysis. Doctoral thesis, Sveučilište u Zagrebu, Prirodoslovno matematički fakultet.

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Abstract

In this dissertation, the stereochemistry of 2,2'-iminodiacetamide and bis(pyridin-2-ylmethyl) amine ligand complexes was studied, focusing on the influence of substituents on the ligand, anion and noncovalent interactions. The prepared ligands were divided into four groups. Eight differently substituted iminodiacetamide ligands (A) were prepared. A cis-fac crystal structure was obtained with the H-substituted ligand, while the other ligands gave trans-fac isomers. Complexes with Cu(II) and Zn(II) were prepared with a isopropyl-substituted bis(2-pyridine- 2-ylmethyl)amine ligand (B). Depending on the anion, crystal structures of monomers, dimers, a cis-fac-ML2 complex and a cyclic trimer that binds CO2 from air were obtained. Fe(II) complexes with two cyclohexanediamine derivatives (C) were investigated in catalytic reactions as flavone synthase mimics. Furthermore, 7 bis(2-pyridine-2-ylmethyl)amine and 5 iminodiacetamide ligands (D) with different lengths of CH2 linkers and different chiral groups were prepared to study the influence of structural changes on the coordination properties of these ligands in Cu(II) and Zn(II) complexes. Ligands with 3 CH2 groups formed ML2 complexes, while ligands with 2 CH2 groups showed side chain coordination and formation of ML complexes. Complexes of ML stoichiometry showed DNA cleavage activity.

Item Type:	Thesis (Doctoral thesis)
Uncontrolled Keywords:	isomers; chirality; metal complexes; stereochemistry; tridentate ligands
Subjects:	NATURAL SCIENCES > Chemistry > Inorganic Chemistry
Divisions:	Division of Materials Chemistry
Projects:	Project title Project leader Project code Project type Minimalni umjetni enzimi: Proširenje primjene posredne indukcije na nove supstrate i nove asimetrične reakcije-MArtEn Srećko Kirin IP-2014-09-1461 HRZZ
Depositing User:	Natalija Pantalon Juraj
Date Deposited:	05 Jul 2022 14:03
URI:	http://fulir.irb.hr/id/eprint/7395

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