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Epigenetic markers in head and neck cancer: special view on HPV-associated oropharyngeal cancer

Milutin Gašperov, Nina; Sabol, Ivan; Tomaić, Vjekoslav; Grce, Magdalena (2022) Epigenetic markers in head and neck cancer: special view on HPV-associated oropharyngeal cancer. Liječnički vjesnik, 144 (3-4). pp. 96-105. ISSN 0024-3477

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Despite continuous efforts to identify molecular markers for the early detection of head and neck cancer (HNC), and improved therapy, the overall survival and prognosis of HNC patients still remain poor. Scientific evidences suggest that HPV-associated HNC had better prognosis and survival. Furthermore, epigenetic alterations are generally frequently involved in carcinogenesis, tumor progression and resistance to therapy. Thus, understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis promise the identification of epigenetic markers for the early detection of cancer and improvement of therapeutic approaches to fight cancer. In this review, the focus is on the current knowledge on epigenetic modifications regarding DNA methylation and microRNAs observed in HNC, particularly in HPV-positive oropharyngeal cancer.

Item Type: Article
Uncontrolled Keywords: HPV ; HNSCC ; oropharynx
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Oncology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima-HPVHNCVjekoslav TomaićIP-2016-06-2246HRZZ
Epigenetičke promjene karcinoma pločastih stanica glave i vrata-EpiC-HNSCCMagdalena GrceIP-2013-11-4758HRZZ
Depositing User: Ivan Sabol
Date Deposited: 06 Apr 2022 08:48
DOI: 10.26800/lv-144-3-4-6

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