hrvatski jezikClear Cookie - decide language by browser settings

Association of lipid peroxidation product 4-hydroxynonenal with post-traumatic stress disorder

Nikolac Perković, Matea; Milković, Lidija; Uzun, Suzana; Mimica, Ninoslav; Pivac, Nela; Waeg, Georg; Žarković, Neven (2021) Association of lipid peroxidation product 4-hydroxynonenal with post-traumatic stress disorder. Biomolecules, 11 (9). ISSN 2218-273X

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (719kB) | Preview


Repeated activation of the hypothalamic-pituitary-adrenal axis system, sleep disturbances, and other symptoms related to posttraumatic stress disorder (PTSD) elevate reactive oxygen species, increase inflammation, and accelerate cellular aging, leading to neuroprogression and cognitive decline. However, there is no information about possible involvement of 4-hydroxynonenal (4-HNE), the product of lipid peroxidation associated with stress-associated diseases, in the complex etiology of PTSD. Therefore, the aim of this study was to compare the plasma levels of 4-HNE between war veterans with PTSD (n = 62) and age-, sex- and ethnicity- matched healthy control subjects (n = 58) in order to evaluate the potential of HNE-modified proteins as blood-based biomarker of PTSD. The genuine 4-HNE-Enzyme-Linked Immunosorbent Assay (HNE-ELISA), based on monoclonal antibody specific for HNE-histidine (HNE-His) adducts, was used to determine plasma HNE-protein conjugates. Our results revealed significantly elevated levels of 4-HNE in patients with PTSD. Moreover, the accumulation of plasma 4-HNE seems to increase with aging but in a negative correlation with BMI, showing specific pattern of change for individuals diagnosed with PTSD. These findings suggest that oxidative stress and altered lipid metabolism reflected by increase of 4-HNE might be associated with PTSD. If confirmed with further studies, elevated 4-HNE plasma levels might serve as a potential biomarker of PTSD.

Item Type: Article
Uncontrolled Keywords: posttraumatic stress disorder (PTSD) ; 4-hydroxynonenal (4-HNE) ; oxidative stress ; lipid peroxidation ; ELISA ; biomarker ; human plasma samples
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Genomski i glikanski biomarkeri PTSP-a-GlycoGenePTSDNela PivacIP-2014-09-4289HRZZ
Depositing User: Matea Nikolac Perković
Date Deposited: 04 Apr 2022 08:44
DOI: 10.3390/biom11091365

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font