Tadijan, Ana (2019) Utjecaj utišavanja integrinskih podjedinica α u stanicama melanoma čovjeka na osjetljivost na protutumorske lijekove i pokretljivost. Doctoral thesis, Institut Ruđer Bošković, Zagreb.
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Abstract
Chemotherapy is not a preffered treatment option for metastatic melanoma, but is used in the treatment of melanoma which do not respond to targeted therapy. This disertation studies, in a panel of four human melanoma cell lines, the effect of integrin subunits α (α3, α4 or αv) knockdown on the modulation of sensitivity to chemoterapy drugs (cisplatin, paclitaxel or vincristine) and motility. In melanoma cell line RPMI-7951, in which integrin αv knockdown increases sensitivity to cisplatin, paclitaxel or vincristine, the composition of integrin αv adhesion complexes (IAC), i.e. adhesome, was analysed. Results of this work contribute to the understanding of integrin signaling pathways in melanoma and to the development of the combinational therapy for melanoma.
| Item Type: | Thesis (Doctoral thesis) | ||||||||
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| Uncontrolled Keywords: | melanoma; integrin α3; α4; αv; αvβ3; αvβ5; integrin switching; integrin mediated drug resistance; cisplatin paclitaxel; vincristine; migration; focal adhesions; integrin adhesion complexes; adhesome | ||||||||
| Subjects: | NATURAL SCIENCES > Biology NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Ana Tadijan | ||||||||
| Date Deposited: | 04 Jul 2022 12:13 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/7136 |
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