MiR-7 in Cancer Development

Korać, Petra; Antica, Mariastefania; Matulić, Maja (2021) MiR-7 in Cancer Development. Biomedicines, 9 (3). ISSN 2227-9059

Preview

PDF - Published Version - article Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

MicroRNAs (miRNAs) are short non-coding RNA involved in the regulation of specific mRNA translation. They participate in cellular signaling circuits and can act as oncogenes in tumor development, so-called oncomirs, as well as tumor suppressors. miR-7 is an ancient miRNA involved in the fine-tuning of several signaling pathways, acting mainly as tumor suppressor. Through downregulation of PI3K and MAPK pathways, its dominant role is the suppression of proliferation and survival, stimulation of apoptosis and inhibition of migration. Besides these functions, it has numerous additional roles in the differentiation process of different cell types, protection from stress and chromatin remodulation. One of the most investigated tissues is the brain, where its downregulation is linked with glioblastoma cell proliferation. Its deregulation is found also in other tumor types, such as in liver, lung and pancreas. In some types of lung and oral carcinoma, it can act as oncomir. miR-7 roles in cell fate determination and maintenance of cell homeostasis are still to be discovered, as well as the possibilities of its use as a specific biotherapeutic.

Item Type:	Article
Uncontrolled Keywords:	microRNAs ; miR-7 ; gene expression ; tumor suppressor ; cancer cell
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Obnova timusa za preciznu medicinu u liječenju tumora i leukemija-THYMINNOVA Mariastefania Antica IP-2020-02-2431 HRZZ
Depositing User:	Lovorka Čaja
Date Deposited:	29 Mar 2022 08:43
URI:	http://fulir.irb.hr/id/eprint/7123
DOI:	10.3390/biomedicines9030325

Actions (login required)

View Item