Prognostic factors for post-recurrence survival in stage II and III colorectal carcinoma patients

Nikolić, Neda; Radosavljević, Davorin; Gavrilović, Dušica; Nikolić, Vladimir; Stanić, Nemanja; Spasić, Jelena; Čačev, Tamara; Castellvi-Be, Sergi; Čavić, Milena; Janković, Goran (2021) Prognostic factors for post-recurrence survival in stage II and III colorectal carcinoma patients. Medicina, 57 (10). ISSN 1648-9144

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Abstract

This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients.

Item Type:	Article
Uncontrolled Keywords:	post-recurrence survival ; colorectal cancer ; prognostic factor
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Dr Tamara Čačev
Date Deposited:	28 Mar 2022 12:25
URI:	http://fulir.irb.hr/id/eprint/7111
DOI:	10.3390/medicina57101108

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