Vukšić, Antonija; Lovrić, Jasna; Konjevoda, Paško; Blažević, Nina; Bilušić, Marinko; Bradamante, Vlasta (2019) Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats. Arhiv za higijenu rada i toksikologiju, 70 (1). pp. 30-35. ISSN 0004-1254
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Abstract
The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Simvastatin and fenofibrate caused an increase in brain BuChE activity in both normo- and hyperlipidemic rats regardless of the substrate. The increase with BTCh as substrate was significant and practically the same in normolipidemic and hyperlipidemic rats after simvastatin treatment (14–17% vs controls). Simvastatin and fenofibrate also increased liver and plasma BuChE activity in both normolipidemic and hyperlipidemic rats regardless of the substrate. In most cases the increase was significant. Considering the important role of BuChE in cholinergic transmission as well as its pharmacological function, it is necessary to continue investigations of the effects of lipid- lowering drugs on BuChE activity.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | acetylthiocoline ; butyrylthiocholine ; lipid-lowering drugs ; Wistar rats ; Zucker rats | ||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences INTERDISCIPLINARY AREAS OF KNOWLEDGE > Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area |
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| Divisions: | Division of Molecular Medicine | ||||||||
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| Depositing User: | Paško Konjevoda | ||||||||
| Date Deposited: | 21 Mar 2022 13:50 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/7085 | ||||||||
| DOI: | 10.2478/aiht-2019-70-3215 |
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