Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography

Jurin, Mladenka; Kontrec, Darko; Dražić, Tonko; Roje, Marin (2020) Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography. Croatica chemica acta, 93 (3). pp. 203-213. ISSN 0011-1643

Preview

PDF - Published Version - article Available under License Creative Commons Attribution. Download (3MB) | Preview

Abstract

In this study the enantioseparation of (±)-trans-β-lactam ureas 1a–g by supercritical fluid chromatography (SFC) was examined using different polysaccharide based chiral stationary phases (CSPs), and CO2/alcohol (70:30, V/V) as the mobile phase. The influence of CSP type (coated or immobilized), modifiers (alcohols), additive (isopropylamine), temperature and backpressure on enantioseparation were examined. From five tested columns, only the column filled with tris-(4-methylphenylcarbamoyl) cellulose selector proved superior in terms of broad range substrate acceptability and selectivity.

Item Type:	Article
Uncontrolled Keywords:	β-lactam ureas ; enantioseparation ; SFC chromatography ; chiral stationary phases (CSP's)
Subjects:	NATURAL SCIENCES > Interdisciplinary Natural Sciences
Divisions:	Division of Materials Chemistry Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Bioprospecting Jadranskog mora Čož-Rakovac, Rozelinda; Dragović-Uzelac, Verica; Šantek, Božidar; Jokić, Stela; Jerković, Igor; Kraljević Pavelić, Sandra KK.01.1.1.01.0002 EK Znanstveni centar izvrsnosti za bioprospecting mora Čož-Rakovac, Rozelinda; Roje, Marin N/A MZOS
Depositing User:	Darko Kontrec
Date Deposited:	28 Dec 2021 10:39
URI:	http://fulir.irb.hr/id/eprint/6820
DOI:	10.5562/cca3781

Actions (login required)

View Item