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Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography

Jurin, Mladenka; Kontrec, Darko; Dražić, Tonko; Roje, Marin (2020) Enantioseparation of (±)-trans-β-lactam Ureas by Supercritical Fluid Chromatography. Croatica chemica acta, 93 (3). pp. 203-213. ISSN 0011-1643

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Abstract

In this study the enantioseparation of (±)-trans-β-lactam ureas 1a–g by supercritical fluid chromatography (SFC) was examined using different polysaccharide based chiral stationary phases (CSPs), and CO2/alcohol (70:30, V/V) as the mobile phase. The influence of CSP type (coated or immobilized), modifiers (alcohols), additive (isopropylamine), temperature and backpressure on enantioseparation were examined. From five tested columns, only the column filled with tris-(4-methylphenylcarbamoyl) cellulose selector proved superior in terms of broad range substrate acceptability and selectivity.

Item Type: Article
Uncontrolled Keywords: β-lactam ureas ; enantioseparation ; SFC chromatography ; chiral stationary phases (CSP's)
Subjects: NATURAL SCIENCES > Interdisciplinary Natural Sciences
Divisions: Division of Materials Chemistry
Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Bioprospecting Jadranskog moraČož-Rakovac, Rozelinda; Dragović-Uzelac, Verica; Šantek, Božidar; Jokić, Stela; Jerković, Igor; Kraljević Pavelić, SandraKK.01.1.1.01.0002EK
Znanstveni centar izvrsnosti za bioprospecting moraČož-Rakovac, Rozelinda; Roje, MarinN/AMZOS
Depositing User: Sofija Konjević
Date Deposited: 28 Dec 2021 10:39
URI: http://fulir.irb.hr/id/eprint/6820
DOI: 10.5562/cca3781

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