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(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

(COST CA18117) Sabol, Maja; Calleja-Agius, Jean; Di Fiore, Riccardo; Suleiman, Sherif; Ozcan, Sureyya; Ward, Mark P.; Ozretić, Petar (2021) (In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers. Cancers, 13 (20). ISSN 2072-6694

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Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100, 000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints. Dysregulation of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expres-sion through several mechanisms and therefore add another level of complexity to the regula-tory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an empha-sis on ROCs.

Item Type: Article
Uncontrolled Keywords: rare ovarian cancers ; long non-coding RNAs ; lncRNAs ; competing endogenous RNA ; ceRNA ; ovarian cancer biomarkers ; lncRNA-based therapy
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Sofija Konjević
Date Deposited: 09 Nov 2021 10:43
DOI: 10.3390/cancers13205040

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