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Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge

Pešut, Ena; Đukić, Anamaria; Lulić, Lucija; Skelin, Josipa; Šimić, Ivana; Gašperov, Nina Milutin; Tomaić, Vjekoslav; Sabol, Ivan; Grce, Magdalena (2021) Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge. Viruses-Basel, 13 (11). ISSN 1999-4915

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Abstract

Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, including Croatia, and worldwide. Nowadays, the causative role of a subset of oncogenic or high-risk (HR) HPV types, led by HPV-16 and HPV-18, of different anogenital and head and neck cancers is well accepted. Two major viral oncoproteins, E6 and E7, are directly involved in the development of HPV-related malignancies by targeting synergistically various cellular pathways involved in the regulation of cell cycle control, apoptosis, and cell polarity control networks as well as host immune response. This review is aimed at describing the key elements in HPV-related carcinogenesis and the advances in cancer prevention with reference to past and ongoing research in Croatia

Item Type: Article
Uncontrolled Keywords: human papillomaviruses (HPV) ; oncoproteins ; proteomics ; epigenetics ; biomarkers ; cancer ; therapeutics ; immunology
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Gynecology and Obstetrics
BIOMEDICINE AND HEALTHCARE > Public Health and Health Care > Epidemiology
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Multifaktorna analiza HPV inficiranih stanica u nastanku raka vrata materniceSabol, IvanIP-2019-04-3403HRZZ
Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestimaTomaić, VjekoslavIP-2016-06-2246HRZZ
Epigenetičke promjene karcinoma pločastih stanica glave i vrataGrce, MagdalenaIP-2013-11-4758HRZZ
Depositing User: Ivan Sabol
Date Deposited: 11 Nov 2021 08:34
Last Modified: 11 Nov 2021 08:34
URI: http://fulir.irb.hr/id/eprint/6597
DOI: 10.3390/v13112234

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