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Anaphase B: Long-standing models meet new concepts

Vukušić, Kruno; Tolić, Iva Marija (2021) Anaphase B: Long-standing models meet new concepts. Seminars in Cell & Developmental Biology, 117 . pp. 127-139. ISSN 1084-9521

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Mitotic cell divisions ensure stable transmission of genetic information from a mother to daughter cells in a series of generations. To ensure this crucial task is accomplished, the cell forms a bipolar structure called the mitotic spindle that divides sister chromatids to the opposite sides of the dividing mother cell. After successful establishment of stable attachments of microtubules to chromosomes and inspection of connections between them, at the heart of mitosis, the cell starts the process of segregation. This spectacular moment in the life of a cell is termed anaphase, and it involves two distinct processes: depolymerization of microtubules bound to chromosomes, which is also known as anaphase A, and elongation of the spindle or anaphase B. Both processes ensure physical separation of disjointed sister chromatids. In this chapter, we review the mechanisms of anaphase B spindle elongation primarily in mammalian systems, combining different pioneering ideas and concepts with more recent findings that shed new light on the force generation and regulation of biochemical modules operating during spindle elongation. Finally, we present a comprehensive model of spindle elongation that includes structural, biophysical, and molecular aspects of anaphase B.

Item Type: Article
Uncontrolled Keywords: Anaphase B Spindle elongation Motor proteins Microtubule sliding Chromosome segregation Microtubule pushing Microtubule pulling
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
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A new class of microtubules in the spindle exerting forces on kinetochoresTolić, Iva Marija647077EK
Depositing User: Sofija Konjević
Date Deposited: 25 Aug 2021 08:21
DOI: 10.1016/j.semcdb.2021.03.023

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