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An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma

(COST CA18117) Di Fiore, Riccardo; Suleiman, Sherif; Felix, Ana; O'Toole, Sharon; O'Leary, John J; Ward, Mark P; Beirne, James; Sabol, Maja; Ozretić, Petar; Yordanov, Angel; Vasileva-Slaveva, Mariela; Kostov, Stoyan; Nikolova, Margarita; Said-Huntingford, Ian; Ayers, Duncan; Ellul, Bridget; Pentimalli, Francesca; Giordano, Antonio; Calleja-Agius, Jean (2021) An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma. International journal of molecular sciences, 22 (12). ISSN 1422-0067

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Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.

Item Type: Article
Uncontrolled Keywords: choriocarcinoma ; rare cancer ; long non-coding RNA ; oncogenes or tumor suppressor genes ; lncRNA-based therapy
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Depositing User: Petar Ozretić
Date Deposited: 06 Jul 2021 11:28
DOI: 10.3390/ijms22126506

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