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ADP-ribosylation systems in bacteria and viruses

Mikolčević, Petra; Hloušek-Kasun, Andrea; Ahel, Ivan; Mikoč, Andreja (2021) ADP-ribosylation systems in bacteria and viruses. Computational and Structural Biotechnology Journa, 19 . pp. 2366-2383. ISSN 2001-0370

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ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity. It was repeatedly adopted via lateral transfer by eukaryotes, including humans, where it has a pivotal role in epigenetics, DNA-damage repair, apoptosis, and other crucial pathways including the immune response to pathogenic bacteria and viruses. In other words, the same ammunition used by pathogens is adapted by eukaryotes to fight back. While we know quite a lot about the eukaryotic system, expanding rather patchy knowledge on bacterial and viral ADP-ribosylation would give us not only a better understanding of the system as a whole but a fighting advantage in this constant arms race. By writing this review we hope to put into focus the available information and give a perspective on how this system works and can be exploited in the search for therapeutic targets in the future. The relevance of the subject is especially highlighted by the current situation of being amid the world pandemic caused by a virus harbouring and dependent on a representative of such a system.

Item Type: Article
Uncontrolled Keywords: ADP-ribosylation ; ADP-ribosyl transferase ; ADP-ribosyl hydrolase ; PARP ; PARG ; Macrodomain ; Toxin-antitoxin system
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Istraživanje uloge proteinske modifikacije ADP-ribozilacije kod bakterijaMikoč, AndrejaIP-2016-06-4242HRZZ
Inhibitori koronavirusnih makrodomena – novi pristup liječenju bolesti uzrokovane koronavirusimaMikoč, AndrejaIP-CORONA-2020-04-2041HRZZ
Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolorMikoč, Andreja; Mikolčević, Petra867468EK
Depositing User: Andreja Mikoč
Date Deposited: 06 Jul 2021 11:07
DOI: 10.1016/j.csbj.2021.04.023

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