ADP-ribosylation systems in bacteria and viruses

Mikolčević, Petra; Hloušek-Kasun, Andrea; Ahel, Ivan; Mikoč, Andreja (2021) ADP-ribosylation systems in bacteria and viruses. Computational and Structural Biotechnology Journa, 19 . pp. 2366-2383. ISSN 2001-0370

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Abstract

ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity. It was repeatedly adopted via lateral transfer by eukaryotes, including humans, where it has a pivotal role in epigenetics, DNA-damage repair, apoptosis, and other crucial pathways including the immune response to pathogenic bacteria and viruses. In other words, the same ammunition used by pathogens is adapted by eukaryotes to fight back. While we know quite a lot about the eukaryotic system, expanding rather patchy knowledge on bacterial and viral ADP-ribosylation would give us not only a better understanding of the system as a whole but a fighting advantage in this constant arms race. By writing this review we hope to put into focus the available information and give a perspective on how this system works and can be exploited in the search for therapeutic targets in the future. The relevance of the subject is especially highlighted by the current situation of being amid the world pandemic caused by a virus harbouring and dependent on a representative of such a system.

Item Type:

Article

Uncontrolled Keywords:

ADP-ribosylation ; ADP-ribosyl transferase ; ADP-ribosyl hydrolase ; PARP ; PARG ; Macrodomain ; Toxin-antitoxin system

Subjects:

NATURAL SCIENCES > Biology

Divisions:

Division of Molecular Biology

Projects:

Project title	Project leader	Project code	Project type
Istraživanje uloge proteinske modifikacije ADP-ribozilacije kod bakterija	Mikoč, Andreja	IP-2016-06-4242	HRZZ
Inhibitori koronavirusnih makrodomena – novi pristup liječenju bolesti uzrokovane koronavirusima	Mikoč, Andreja	IP-CORONA-2020-04-2041	HRZZ
Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor	Mikoč, Andreja; Mikolčević, Petra	867468	EK