Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

Topolovčan, Nikola; Gredičak, Matija (2021) Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones. Organic & Biomolecular Chemistry, 19 (21). pp. 4637-4651. ISSN 1477-0520

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Abstract

This review focuses on the synthesis of 3-hydroxyisoindolinones, and their application as substrates in stereoselective catalytic transformations reported from 2010 to date. These compounds have attracted much attention among synthetic chemists, as they are integral structural parts of a number of natural products and biologically active compounds. The first part of this review covers methods based on electrochemical, photochemical, and thermal reactions for the synthesis of 3-hydroxyisoindolinones. The second part focuses on their employment as substrates in transition metal-catalyzed and organocatalyzed stereoselective transformations for the preparation of chiral 3-substituted isoindolinone derivatives.

Item Type:	Article
Uncontrolled Keywords:	3-hydroxyisoindolinones
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Nove strategije za pripravu tetrasupstituiranih kiralnih centara: asimetrične katalitičke reakcije usmjerene protuanionom-NSYNC-ACDC Matija Gredičak IP-2018-01-4053 HRZZ Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije-CAT PHARMA Srećko Kirin KK.01.1.1.04.0013 EK
Depositing User:	Matija Gredičak
Date Deposited:	01 Jul 2021 13:03
URI:	http://fulir.irb.hr/id/eprint/6459
DOI:	10.1039/D1OB00164G

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