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Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis

Kesić, Maja; Baković, Petra; Stojković, Ranko; Štefulj, Jasminka; Čičin-Šain, Lipa (2021) Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis. International journal of molecular sciences, 22 (10). ISSN 1422-0067

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Abstract

Central and peripheral serotonin (5HT) have opposing functions in the regulation of energy homeostasis. Both increasing 5HT signaling in the brain and decreasing 5HT signaling in the periphery have been proposed as potential treatments for obesity. This study investigates the relationship between constitutionally high or low 5HT activity and systemic net energy balance. Two sublines of rats with high and low whole-body 5HT tone, obtained by selective breeding for platelet 5HT parameters, were examined for fat accumulation in different white adipose tissue (WAT) depots, glucose/insulin tolerance, blood metabolic parameters, and expression of various metabolic genes. High-5HT animals, unlike their low-5HT counterparts, developed widespread intra- abdominal obesity associated with glucose and insulin intolerance, which worsened with age. They also had elevated blood glucose and lipid parameters but showed no significant changes in circulating leptin, resistin, and adipsin levels. Surprisingly, adiponectin levels were increased in plasma but reduced in the WAT of high-5HT rats. A limited number of metabolic genes belonging to different functional classes showed differential expression in WAT of high- 5HT compared to low-5HT rats. Overall, a constitutive increase in 5HT tone is associated with a positive energy balance acting through subtle dysregulation of a broad spectrum of metabolic pathways.

Item Type: Article
Uncontrolled Keywords: serotonin ; obesity ; metabolism ; genetic rat model ; adipose tissue
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Serotonergična modulacija pretilosti: međuovisnost regulatornih molekula i putevaČičin-Šain, LipaIP-2014-09-7827HRZZ
Depositing User: Maja Kesić
Date Deposited: 31 May 2021 10:12
Last Modified: 06 Aug 2021 12:48
URI: http://fulir.irb.hr/id/eprint/6422
DOI: 10.3390/ijms22105400

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