Implementing Curcumin in Translational Oncology Research

Trošelj, Koraljka Gall; Samaržija, Ivana; Tomljanović, Marko; Kujundžić, Renata Novak; Đaković, Nikola; Mojzeš, Anamarija (2020) Implementing Curcumin in Translational Oncology Research. Molecules, 25 (22). ISSN 1420-3049

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Abstract

Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established a good foundation for further research focusing on implementing curcumin in clinical oncology. However, the issues regarding timely data reporting and lack of disclosure of the exact curcumin formulations used in these studies should not be neglected. This article is a snapshot of the current status of publicly available data on curcumin clinical trials and a detailed presentation of results obtained so far with some curcumin formulations. Phenomena related to the observed effects of curcumin shown in clinical trials are presented, and its modifying effect on gut microbiota and metabolic reprogramming is discussed. Based on available data, there is a strong indication that curcumin and its metabolites present molecules that do not necessarily need to be abundant in order to act locally and benefit systemically. Future clinical studies should be designed in a way that will take that fact into consideration.

Item Type:	Article
Uncontrolled Keywords:	cancer therapy ; clinical trials ; microbiota ; IL-17 ; nicotinamide N-methyltransferase ; metabolic reprogramming ; curcumin formulations
Subjects:	NATURAL SCIENCES > Interdisciplinary Natural Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Koraljka Gall Trošelj
Date Deposited:	07 Jan 2021 14:38
URI:	http://fulir.irb.hr/id/eprint/6159
DOI:	10.3390/molecules25225240

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