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Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males

Podobnik, Josip; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Dodig Ćurković, Katarina; Ćurkovic, Mario; Kovač, Vlatka; Švob Štrac, Dubravka; Čusek, Melita; Bortolato, Marco; Pivac, Nela (2020) Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. Biomolecules, 10 (11). ISSN 2218-273X

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Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building on this evidence, we assessed whether conduct disorder (CD), juvenile delinquency adjudications, or detention in a correctional facility were associated with either platelet MAO-B activity or the MAOB rs1799836 polymorphism. The study enrolled 289 medication-free male youths, including 182 individuals detained in a correctional facility (with or without a diagnosis of CD). Of the remaining 107 participants, 26 subjects had a diagnosis of CD, and 81 were mentally healthy controls. Platelet MAO-B activity was determined by spectrophotofluorometry, while MAOB rs1799836 was genotyped using qPCR. Platelet MAO-B activity, corrected for age and smoking, was significantly higher in juvenile detainees (p < 0.001), irrespective of CD diagnosis. MAOB rs1799836 was not associated with platelet MAO-B activity or with detention in a correctional facility, CD diagnosis, or delinquent behavior. These data suggest that detention in a juvenile correctional facility increases platelet MAO-B activity in male adolescents. Future studies are needed to determine the mechanisms and functional significance of MAO-B peripheral elevation in juvenile male detainees

Item Type: Article
Uncontrolled Keywords: juvenile correctional facility ; delinquent behavior ; platelet MAO-B activity ; MAOB rs1799836 polymorphism ; conduct disorder
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećajaPivac, Nela098-0982522-2455MZOS
Depositing User: Dubravka Švob Štrac
Date Deposited: 29 Dec 2020 08:22
DOI: 10.3390/biom10111555

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