Rho Family of Ras-Like GTPases in Early-Branching Animals

Beljan, Silvestar; Herak Bosnar, Maja; Ćetković, Helena (2020) Rho Family of Ras-Like GTPases in Early-Branching Animals. Cells, 9 (10). ISSN 2073-4409

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Abstract

Non-bilaterian animals consist of four phyla ; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.

Item Type:	Article
Uncontrolled Keywords:	non-bilaterian animals ; Rho GTPases ; Cdc24 ; Rho ; Rac ; RhoBTB ; Miro ; Porifera ; Ctenophora ; Placozoa ; Cnidaria
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Medicine
Depositing User:	Maja Herak Bosnar
Date Deposited:	11 Nov 2020 15:28
URI:	http://fulir.irb.hr/id/eprint/5997
DOI:	10.3390/cells9102279

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